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Natural killer (NK) T (NKT) cells are a conserved population of innate-like T cells that express CD1d-restricted semi-invariant αβ T-cell receptors (TCRs), using mostly the Vα14-Jα18 chain in mouse (Vα24-Jα18 in human) combined with variable Vβ8, Vβ7, and Vβ2 (Vβ11 in human) chains, which confer recognition of conserved self and foreign lipids (1 phenotype along with receptors of the NK cell lineage.The innate-like effector functions of NKT cells are illustrated by the cells’ ability to promptly secrete large quantities of both IL-4 and IFN-γ either after TCR activation or on exposure to tissue- and antigen-presenting cell-derived cytokines, such as IL-25 IL-33 and IL-12 IL-18, respectively. Phone: 617.643.2579; Fax: 617.643.3170; E-mail: Bardeesy. Phone: 617.643.3156; Fax: 617.643.3170; E-mail: Tzatsos. (A) Heat map of quantitative RT-PCR data showing relative expression of HDM family members in human PDAC cell lines versus HPDE cells. (B) KDM2B transcript levels in a series of human PDAC specimens compared with normal pancreatic tissue, determined by RNA-seq (samples from MGH tumor bank).
Address correspondence to: Alexandros Tzatsos or Nabeel Bardeesy, 185 Cambridge Street, Boston, Massachusetts 02114, USA. Quantitative real-time PCR analysis revealed that HDMs as a group were broadly dysregulated in PDAC cell lines compared with immortal, but not transformed, human pancreatic ductal epithelial (HPDE) and human pancreatic nestin-expressing (HPNE) cells (Figure 1A).SET and MYND domain containing protein 3 (SMYD3) is a histone methyltransferase, which has been implicated in cell growth and cancer pathogenesis.Increasing evidence suggests that SMYD3 can influence distinct oncogenic processes by acting as a gene-specific transcriptional regulator.The most frequent genetic abnormality in T-ALL is the dysregulation of transcription factor genes.We previously identified the “core transcriptional regulatory circuits” controlled by the oncogenic transcription factor TAL1 in T-ALL.
Search for elucidating altered transcriptional programs:
Together, these studies define expanded roles for SMYD3 and PC4 in gene regulation and provide an unprecedented documentation of their cooperative functions in stimulating oncogenic transcription.